Prevalence of FOXC1 Variants in Individuals With a Suspected Diagnosis of Primary Congenital Glaucoma
نویسندگان
چکیده
منابع مشابه
MYOC and FOXC1 gene analysis in primary congenital glaucoma
PURPOSE To screen the myocilin (MYOC) and forkhead box protein C1 (FOXC1) genes for sequence variations in primary congenital glaucoma (PCG). METHODS Seventy five PCG patients were screened for MYOC variations and 54 cases (negative or heterozygous for cytochrome P4501B1 mutations) for FOXC1 mutations by polymerase chain reaction (PCR) and DNA sequencing. RESULTS Five single nucleotide poly...
متن کاملprevalence of atopic dermatitis in children with type 1 diabetes mellitus in southeastern of iran (kerman province): a case-control study
چکیده ندارد.
15 صفحه اولCommon TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma
PURPOSE Primary open-angle glaucoma (POAG) is a common but complex disease with a strong genetic component. Notably, few genes have been robustly associated with POAG. An obvious group of genes to test as susceptibility factors for POAG are the developmental genes forkhead box C1 (FOXC1), transforming growth factor-beta 2 (TGFβ2), and bone morphogenic protein 4 (BMP4). These genes are known to ...
متن کاملThe transcription factor gene FOXC1 exhibits a limited role in primary congenital glaucoma.
PURPOSE Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (n = 301) revealed cases that were either homozygous (n = 73), compound heter...
متن کاملPrevalence of Congenital Heart Disease in Primary School Children
This article has no abstract.
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ژورنال
عنوان ژورنال: JAMA Ophthalmology
سال: 2019
ISSN: 2168-6165
DOI: 10.1001/jamaophthalmol.2018.5646